Maggots provide key to MRSA antibiotic

Scientists at Swansea University have discovered a new type of antibiotic in maggot secretions that can tackle up to 12 different strains of MRSA, as well as E. coli and C. difficile. The antibiotic, named Seraticin, is derived from the maggot secretions of the common green bottle fly (Lucilia sericata) and scientists hope to develop it into an injection, pill or ointment.

So far, they have purified Seraticin and undertaken the study of its structure and the mechanism by which it prevents infection. The next steps will be to complete the identification of the compound and develop a way to synthesise it.

It can then be tested on human cells and eventually in clinical trials in order to determine its medical effectiveness and properties as a novel antibiotic. The research was funded by leading charity Action Medical Research, with support from the Rosetrees Trust.

Dr Yolande Harley of Action Medical Research said: “The discovery of a potential new antibiotic is an exciting advance. It could mean a possible novel treatment for people with chronic wounds that are infected with MRSA or other bugs. By developing the pure antibiotic into a formula, such as a cream, it could reduce the contact patients need to have with live maggots to heal wounds. It could also offer a potential treatment, such as an injection or pill, for internal infections like C. difficile.”

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