Two studies have indicated warning signs about the spread of bacteria resistant to carbapenems in both healthcare and community settings across Europe.
Two studies published in Eurosurveillance have analysed new data on spread of such CRE, namely Escherichia coli sequence type (ST)131 producing various carbapenemases and New Delhi metallo-beta-lactamase-1 (NDM-1)-producing Providencia stuartii to inform potential public health action.
In a rapid communication, Kohlenberg et al assessed genomic and epidemiological data from 17 EU/EEA countries and observed an emergence of Escherichia coli that produces carbapenemases. Worldwide, E. coli is the pathogen associated with most deaths attributable to antimicrobial resistance1and the specific type of E. coli that the authors investigated in their study (ST 131) has been detected across the world and is frequently associated with multidrug-resistance.
Kohlenberg et al analysed the sequencing and epidemiological data of almost 600 E. coli ST131 isolates provided by national reference laboratories from Austria, Belgium, Czechia, Denmark, Finland, France, Hungary, Ireland, Germany, Latvia, Lithuania, Luxembourg, the Netherlands, Norway, Portugal, Slovenia and Sweden.2
Detection of E. coli ST131 isolates producing carbapenemases increased over time. One group of isolates stood out for potential association with urinary tract infections in the community inferred from the relatively low median age of patients (57 years), a high proportion of female patients and the frequent detection of isolates from urine samples. The authors note that “community-acquired urinary tract infections might only represent the tip of the iceberg in terms of patient colonisation in the community”.
While Kohlenberg et al acknowledge they did not analyse a random population of E. coli ST131 but pre-selected isolates from the reference laboratories which probably resulted in an isolate collection with a higher likelihood for co-carriage of other resistance markers, they argue that the results of their study across 17 EU/EEA countries “sends another warning about the worsening epidemiological carbapenemase-producing Enterobacterales situation in the EU/EEA. Further spread of E. coli carrying carbapenemase genes would mean that carbapenems could no longer be consistently effective for empiric treatment of severe E. coli infections.”
One type of CRE which has been very rare in Europe thus far – New Delhi metallo-beta-lactamase-1 (NDM-1)-producing Providencia stuartii – has now been detected in several hospitals in Romania. In their genomic investigation, Linkevicius et al3 looked at how NDM-1-producing P. stuartii is spreading in hospitals with the aim to generate timely information to control any further transmission.
In their study, the authors analysed 74 P. stuartii samples they received from six hospitals across Romania. Most (n=72/74) of the retrieved isolates were related to a reported infection among patients, such as lower respiratory tract bloodstream or urinary tract infections. The authors categorised the majority of the infections as healthcare-associated, i.e. the patients acquired them in a hospital or other healthcare setting.
Given their resistance to several antibiotic classes like penicillins, cephalosporins and carbapenems, 90% of the tested isolates in this study were categorised as multidrug-resistant. In their investigation, Linkevicius et al identified four multi-hospital clusters of such resistant isolates detected over a year. This indicates sustained transmission within the Romanian healthcare system over a longer period.
Putting their study results into international context by comparing with data from other countries, the authors could also connect the specific lineage of P. stuartii detected in Romania to isolates found in other countries, i.e. Bulgaria, France, Germany, Ireland, the Netherlands, Switzerland, the United Kingdom and the United States of America.
They conclude that “sustained transmission in hospitals in Romania and the international spread point to high risk of further transmission of NDM-1-producing P. stuartii in healthcare settings. Enhanced infection prevention and control measures should be put in place as soon as cases are detected in healthcare facilities.”
References
1. Kohlenberg, A, et al. Emergence of Escherichia coli ST131 carrying carbapenemase genes, European Union/European Economic Area, August 2012 to May 2024. Euro Surveill. 2024;29(47)
Available from: https://doi.org/10.2807/1560-7917.ES.2024.29.47.2400727
2. Murray CJL, et al. Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis. Lancet. 2022;399(10325):629-55. Available from: http://dx.doi.org/10.1016/S0140-6736(21)02724-0 PMID:35065702
3. Linkevicius, M, et al. Genomic surveillance detects interregional spread of New Delhi metallo-beta-lactamase-1-producing Providencia stuartii in hospitals, Romania, December 2021 to September 2023. Euro Surveill. 2024;29(47):pii=2400587. Available from: https://doi.org/10.2807/1560-7917.ES.2024.29.47.2400587
