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AI improves colorectal cancer screening in Lynch syndrome

People with Lynch syndrome have a higher hereditary risk of colon cancer. Despite regular endoscopic surveillance, it remains elevated in those affected. Researchers at the National Center for Hereditary Tumor Diseases (NZET) at Bonn University Hospital (UKB) have now found that artificial intelligence (AI) can improve the effectiveness of colonoscopy in the presence of Lynch syndrome. The study results have been published online in the United European Gastroenterology Journal.

Hereditary non-polyposis colorectal cancer (HNPCC)", Lynch syndrome (LS) for short, is the most common hereditary colorectal cancer syndrome. LS is responsible for about two to three percent of all colon cancers. It is triggered by defects in genes responsible for repairing the human genetic material DNA. Children of those affected have a 50 percent risk of also having the pathologically altered hereditary disposition, technically known as a mutation, and thus also a high risk of developing colon cancer at a young age.

Therefore, regular monitoring by means of colonoscopy is recommended here every one to two years. "However, despite such regular endoscopic monitoring, the risk of colorectal cancer remains elevated in those affected," said Prof. Jacob Nattermann, head of the Hepatogastroenterology Section at UKB's Medical Clinic I (Director: Prof. Christian Strassburg). The researchers explain this by the fact that colonoscopy still misses a considerable number of adenomas, the potential precursors of colorectal cancer. "Small and flat adenomas in particular are at risk of being overlooked even by experienced gastroenterologists," commented Prof. Nattermann.

Recent data suggest that artificial intelligence (AI)-assisted colonoscopy, also known as computer-aided detection (CADe), may help increase adenoma detection rates (ADR) in the general population. "Therefore, the aim of our study was to evaluate the diagnostic performance of AI-assisted colonoscopy in patients with Lynch syndrome," said Robert Hüneburg, senior physician at UKB's Medical Clinic I. Thus, in close collaboration with the Institute of Medical Informatics, Statistics and Epidemiology at the University of Leipzig, 46 LS patients were studied using standard endoscopy and 50 LS patients with AI-assisted colonoscopy between December 2021 and December 2022.

Here, significantly more of the AI-assisted examinations (36 percent) detected adenomas than the standard examinations (26.1 percent). "This was mainly due to significantly improved detection of flat adenomas," Hüneburg said.

In summary, this study was the first in the world to collect data suggesting that AI-assisted real-time colonoscopy is a promising approach to optimise endoscopic surveillance of LS patients, especially to improve detection of flat adenomas. "Due to the small sample size, based on these results, a larger multicentre study is now planned under the leadership of our department," said Prof. Nattermann.

 

 

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Upcoming Events

Advancing Ultrasound Probe Decontamination Study Day

Horizon Leeds, 2 Kendall Street #3rd Floor Leeds LS10 1JR
12th March 2024

Webinar: How to be Compliant and Sustainable In Healthcare

ONLINE
19th March 2024 & 21st March 2024 10 am CET time o

POCT Innovators: The Power to Disrupt Series

Cloth Hall Court, Leeds. UK
20 March, 2024

Central Sterilising Club - Annual Scientific Meeting 2024

Crowne Plaza at Gerrard’s Cross
15th April 2024 – 16th April 2024

DECON UK 2024

National Conference Centre, Birmingham
17th April 2024

Infection Prevention & Control

National Conference Centre, Birmingham
23rd - 24th April 2024

Access the latest issue of Clinical Services Journal on your mobile device together with an archive of back issues.

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