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Metformin use significantly reduces risk of joint replacement in people with type 2 diabetes

A team of researchers from China, Taiwan and Australia aimed to determine whether metformin use was associated with a lower risk of total knee replacement (TKR) or total hip replacement (THR), as evidence to date has been sparse and inconclusive.

They analysed data from 69,706 participants who received a diagnosis of type 2 diabetes in Taiwan between 2000 and 2012 and compared the risk of TKR and/or THR between people taking metformin and those not taking metformin. The mean age was 63 years and half were women. About 90% of total joint replacements were related to osteoarthritis.

"We found that metformin use in patients with type 2 diabetes mellitus was associated with a significantly reduced risk of joint replacement, suggesting a potential therapeutic effect of metformin in patients with osteoarthritis," writes Dr. Changhai Ding, Clinical Research Center of Zhujiang Hospital, Southern Medical University, Guangzhou, China, with coauthors.

The authors call for randomised controlled trials to determine if metformin use is effective in patients with osteoarthritis.

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Upcoming Events

Central Sterilising Club Annual Scientific Meeting

Crowne Plaza, Newcastle Upon Tyne
3rd - 4th April 2023

DECON UK 2023

Hilton Birmingham Metropole
18th April 2023

Infection Prevention and Control 2023

National Conference Centre, Birmingham
25th - 26th April 2023

Oncology Professional Care

ExCeL London E16 1XL
23-24 May 2023

EBME Expo 2023

Judds Lane, Coventry, England, GB, CV6 6
28th - 29th June 2023

AfPP Annual Conference 2023

University of York
10- 13 August 2023

Access the latest issue of Clinical Services Journal on your mobile device together with an archive of back issues.

Download the FREE Clinical Services Journal app from your device's App store

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