A team of researchers from China, Taiwan and Australia aimed to determine whether metformin use was associated with a lower risk of total knee replacement (TKR) or total hip replacement (THR), as evidence to date has been sparse and inconclusive.
They analysed data from 69,706 participants who received a diagnosis of type 2 diabetes in Taiwan between 2000 and 2012 and compared the risk of TKR and/or THR between people taking metformin and those not taking metformin. The mean age was 63 years and half were women. About 90% of total joint replacements were related to osteoarthritis.
"We found that metformin use in patients with type 2 diabetes mellitus was associated with a significantly reduced risk of joint replacement, suggesting a potential therapeutic effect of metformin in patients with osteoarthritis," writes Dr. Changhai Ding, Clinical Research Center of Zhujiang Hospital, Southern Medical University, Guangzhou, China, with coauthors.
The authors call for randomised controlled trials to determine if metformin use is effective in patients with osteoarthritis.