The activity of disinfectants against microorganisms depends on a number of factors, some of which are intrinsic qualities of the organism, others of which are the chemical and external physical environment.
The “Entourage effect” described by Ethan B Russo in January 20191 is based on the idea of the holism theory, which is credited to Aristotle, who said “the whole is greater than the sum of the parts”.
Quaternary ammonium compounds have been around since the early 20th century and are used in many cleaning products. There are essentially two main groups of disinfectants that use quaternary ammonium type compounds, those that have a silane attached (SiQuats) and those that do not (Quats). While their mode of action (MOA) is essentially the same, the spectrum of species kill, and the level of persistence (length of time they remain in place to continue killing) are very different for each variat