Researchers from Osaka University found that all identified C. butyricum bacteraemia strains were probiotic derivatives using whole-genome sequencing.
Probiotics offer a range of health benefits, but their adverse effects can occasionally lead to bacteraemia, wherein bacteria circulate in the bloodstream throughout the body. In Japan, Clostridium butyricum (C. butyricum) MIYAIRI 588 is commonly used, yet the prevalence and characteristics of bacteraemia caused by this strain, as well as its bacteriological and genetic profile, remain unknown.
A research team from the Graduate School of Medicine, Osaka University, found an association between bacteraemia and probiotics from a study of the genetic materials of bacteria in hospitalised patients with bacteraemia.
From September 2011 to February 2023, Osaka University Hospital documented 6,576 cases of positive blood cultures. Among these, C. butyricum was detected in five cases (0.08%). Whole-genome sequencing revealed that all five strains of C. butyricum-causing bacteraemia were derived from probiotics. In two of these cases, no clear reason for appropriate oral intake of the probiotics could be identified, and one patient died within 90 days after the bacteraemia diagnosis.
"Probiotics can provide a variety of health benefits, but this study shows that even such agents can present with rare but serious adverse events," says study lead author Ryuichi Minoda Sada. "Our findings underscore the risk for bacteraemia resulting from probiotic use, especially in hospitalised patients, necessitating judicious prescription practices."
It is expected that the results of this study will increase awareness of the potential health risks associated with probiotics. It is recommended to avoid aimless and unnecessary prescribing of probiotics, especially in hospitalised patients undergoing immunosuppressive treatment.
The article, “Clostridium butyricum Bacteremia Associated with Probiotic Use, Japan,” was published in Emerging Infectious Diseases at: http://doi.org/10.3201/eid3004.231633
