WHO has published its first global research agenda for the world’s scientists to address the most urgent human health priorities to combat antimicrobial resistance (AMR). It outlines 40 research topics on drug-resistant bacteria, fungi and Mycobacterium tuberculosis that must be answered by 2030, in line with the Sustainable Development Goals.
The WHO Global Research Agenda for AMR in human health will catalyse innovation and implementation research, spanning the epidemiology, burden and drivers of AMR, context-specific and cost-effective strategies to prevent infections and emergence of resistance.
Among the priority areas highlighted include a focus on infection prevention, relating to water, sanitation and hygiene (referred to as ‘WASH’). The WHO has outlined the need to investigate the impact and cost–effectiveness of interventions to ensure safely managed water, sanitation and hygiene (including hand hygiene) and waste management practices in the community setting, on reducing antimicrobial resistance, such as unnecessary antibiotic consumption. ‘WASH’-related interventions in healthcare settings will also be investigated.
Also key is the need to assess the impact of vaccines on preventing infection by resistant pathogens and on reducing the overall use of antimicrobial medicines.
Other priority areas include the discovery of new diagnostic tests and improved treatment regimens, the identification of cost-effective methods to collect data and translate it into policy, as well as how to implement current interventions more efficiently in resource-limited settings.
Ultimately, the generated evidence will inform policies and interventions to strengthen the response to antimicrobial resistance, particularly in low- and middle-income countries.
“Antimicrobial resistance is an urgent public health and economic challenge, and good quality research is a vital part of the response. To help preserve antimicrobials and save lives and livelihoods, this research agenda is a crucial tool for researchers and funders to prioritise research questions, and promptly and efficiently generate evidence that informs policy,” said Dr. Hanan Balkhy, WHO Assistant Director-General for AMR. “This first research agenda from WHO will provide the world’s AMR researchers and funders with the most important topics to focus on and give the world its best chance to combat AMR,” added Dr. Silvia Bertagnolio, Unit Head in WHO AMR Division.
The research agenda was developed based on a review of over 3000 relevant documents published over the past decade. The review identified 2000 unanswered questions or knowledge gaps, which were further consolidated and prioritised by a large group of AMR experts to conclude with the 40 most pivotal research topics. A summary report containing the research priorities is available here.
