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Innovation in point of care sepsis diagnostics

Sepsis is a life-threatening reaction to an infection. Against a background of ongoing diagnostic research, Charlotte Duncan provides an overview and introduces the latest in point-of-care technology.

Sepsis is a life-threatening reaction to an infection, resulting in the immune system overreacting and the beginning of damage to the body’s own tissues and organs. Against a background of ongoing diagnostic research, Charlotte Duncan provides an overview and introduces the latest in point-of-care technology.

Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection.1 According to The UK Sepsis Trust, 250,000 people per year are affected by sepsis, of which 52,000 people die and 60,000 people suffer permanent, life-changing after effects.2 The often quoted aphorism that sepsis kills more people in the UK than bowel, breast and prostate cancer combined3 rather poignantly gives a sense of the scale of the problem. Indeed, the global picture is even more grim with sepsis causing an estimated 11 million deaths each year, and data showing those in vulnerable groups and low-resource settings account for 85% of these cases.4 In May 2017, the World Health Organization (WHO) issued a resolution confirming sepsis is a worldwide issue.5

Given the significant disease burden in the UK, and globally, the diagnostic support to clinicians is lacking.6 Routine tests such as C-reactive protein (CRP), blood count, lactate7 and procalcitonin8 offer limited information on the inflammatory response of the patient in the form of ‘point-intime’ assessments, requiring serial testing to obtain an indication of response to treatment, while most innovation focuses on bloodstream infections and subsequent identification and antimicrobial susceptibility testing (AST). Identification of a pathogen can allow clinicians to optimise antimicrobial therapy. Depending on the identification and AST result of an infecting organism, escalation or de-escalation of antibiotics and adjusting modes of administration can result in improved patient care9 and outcome, and support antimicrobial stewardship.10

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Upcoming Events

AfPP Annual Conference 2022

University of York
8-11 September 2022

Infection 360: What's trending in infection prevention & control

Edgbaston Stadium, Birmingham
27-28 September 2022

IP2022 IS COMING TO BOURNEMOUTH IN OCTOBER 2022

Bournemouth
17-19 October 2022

UKHCA Conference: Listen Up

Pendulum Hotel and Manchester Conference Centre, Manchester
3rd November 2022

MEDICA 2022

Dusseldorf Germany
14th November - 17th November

Future Surgery 2022

ExCel, London
15th - 16th November 2022

Access the latest issue of Clinical Services Journal on your mobile device together with an archive of back issues.

Download the FREE Clinical Services Journal app from your device's App store

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