The website of the Clinical Services Journal

Study boosts understanding of surgical complication

Older patients across China took part in a major multi-centre randomised clinical trial that showed there was no difference in post-operative delirium in older people with a hip fracture if they had a general anaesthesia or a regional anaesthesia.

Post-operative delirium is a common, serious, neurological, complication where people have a sudden change in their brain functions after an operation.  It is more common in older people, and leads to increased death, dementia, post-traumatic stress disorder, a longer length of hospital stay, extra nursing requirements and increased healthcare costs. 

It was commonly thought that one of the causes of delirium is a general anaesthesia. Led by the University of Birmingham and Wenzhou Medical University Second Affiliated Hospital, this randomised trial was  the first of its kind in China. 950 older adult took part, from hospitals in Wenzhou, Wuhan, Lishui, Ningbo, Nanchang, and Taizhou.

The trial was set up to provide clinical evidence with a robust methodology, to help medical professionals select appropriate anaesthesia for older patients to try and reduce the development of delirium. Researchers in Birmingham and WenZhou today published the findings in JAMA. After the hip fracture surgery, delirium occurred in 6.2% of the group who had general anaesthesia, and 5.1% in those who had a regional anaesthesia.  The difference between the two groups could be explained by chance.

The chief investigator of RAGA trial, Professor Fang Gao, from the University of Birmingham, NIHR Senior Investigator, commented: “There is a high incidence of delirium after surgery in hip fracture patients, but we had  no robust evidence demonstrating the effectiveness of  the two most commonly used anaesthetic techniques causing delirium – creating an urgent need to investigate delirium prevention. 

“The causes of delirium remain poorly understood, but our trial highlights that factors such as general anaesthetic agents, that we thought may be associated with delirium, are in fact unlikely to cause delirium. Our trial has also provided clinical evidence on the safety of RA and GA in older patients for hip fracture surgery, helping anaesthetists in selecting appropriate anaesthesia for these patients – particularly those at high risk of POD.”

Dr. Thomas Jackson, associate professor in Geriatric Medicine and Board member of the European Delirium Association, commented; “Delirium is first and foremost a distressing condition for the suffer and their care givers, and to date we have no treatments we know to shorten or stop delirium when it develops. This trial is an important step forward in our understanding of how people develop delirium after an operation.  By demonstrating that a general anaesthetic is not a probable cause of delirium will allow researchers to further study other areas, such as the bodies inflammatory response to the surgery itself, and how this carries over into the brain.”

 

Upcoming Events

Arab Health 2022

Dubai World Trade Centre
24th - 27th January

Knowlex Infection Prevention & Control 2022

National Conference Centre, Birmingham
8th - 9th February

Central Sterilising Club 60th Anniversary Annual Scientific Meeting

Crowne Plaza, Bridge Foot, Stratford-upon-Avon, CV37 6YR
4th - 5th April

iM Med Decontamination Academy Spring Conference

Royal College of Physicians, London
11th May 2022

NPAG Theatres and Decontamination Conference

Coventry Building Society Arena
19th May 2022

EBME Expo 2022

Coventry Building Society Arena, Phoenix Way, Rowleys Green, Coventry CV6 6GE
28th - 29th June

Access the latest issue of Clinical Services Journal on your mobile device together with an archive of back issues.

Download the FREE Clinical Services Journal app from your device's App store

Upcoming Events

Arab Health 2022

Dubai World Trade Centre
24th - 27th January

Knowlex Infection Prevention & Control 2022

National Conference Centre, Birmingham
8th - 9th February

Central Sterilising Club 60th Anniversary Annual Scientific Meeting

Crowne Plaza, Bridge Foot, Stratford-upon-Avon, CV37 6YR
4th - 5th April

iM Med Decontamination Academy Spring Conference

Royal College of Physicians, London
11th May 2022

NPAG Theatres and Decontamination Conference

Coventry Building Society Arena
19th May 2022

EBME Expo 2022

Coventry Building Society Arena, Phoenix Way, Rowleys Green, Coventry CV6 6GE
28th - 29th June

Access the latest issue of Clinical Services Journal on your mobile device together with an archive of back issues.

Download the FREE Clinical Services Journal app from your device's App store

Step Communications Ltd, Step House, North Farm Road, Tunbridge Wells, Kent TN2 3DR
Tel: 01892 779999 Fax: 01892 616177
www.step-communications.com
© 2022 Step Communications Ltd. Registered in England. Registration Number 3893025