Common cancer treatments ‘do not worsen coronavirus infection’

According to a new study from Memorial Sloan Kettering, published in Nature Medicine, patients in active cancer treatment who develop COVID-19 infection don't fare any worse than other hospitalised patients.

Notably, metastatic disease, recent chemotherapy, or major surgery within the previous 30 days did not show a significant association with either hospitalisation or severe respiratory illness due to COVID-19. Researchers say their findings suggest that no one should delay cancer treatment because of concerns about the virus. 

"If you're an oncologist and you're trying to figure out whether to give patients chemotherapy, or if you're a patient who needs treatment, these findings should be very reassuring," says Ying Taur, MD, PhD, an Infectious Disease Specialist at MSK. 

"The course and clinical spectrum of this disease is still not fully understood and this is just one of many studies that will need to be done on the connections between cancer and COVID-19," explained Mini Kamboj, MD, Chief Medical Epidemiologist, Infection Control at MSK. "But the big message now is clear: People shouldn't stop or postpone cancer treatment."

The study looked at 423 MSK patients diagnosed with COVID-19 between March 10 and April 7. Overall, 40% were hospitalised for COVID-19, and 20 percent developed severe respiratory illness. About 9% had to be placed on a mechanical ventilator, and 12% died. The most frequent cancer types included solid tumours such as breast, colorectal, and lung cancer. Lymphoma was the most common hematologic malignancy. Over half of the cases were metastatic solid tumours.

Similar to other studies in the general population, the researchers found that age, race, cardiac disease, hypertension, and chronic kidney disease correlated with severe outcomes. The investigators found that patients taking immunotherapy drugs called immune checkpoint inhibitors were more likely to develop severe disease and require hospitalisation. Further research is required to look at the effects of these drugs. But other cancer treatments, including chemotherapy and surgery, did not contribute to worse outcomes. 

Reference

Taur Y,  and Kamboj M, Determinants of Severity in Cancer Patients with COVID-19 Illness, Nature Medicine, June 24, 2020.