The website of the Clinical Services Journal

Analysing biomarkers for sepsis diagnosis

It is estimated that there are around 123,000 cases of sepsis in England every year, resulting in around 36,900 deaths. In the fight against sepsis, modern haematology and haemostasis technology can assist in providing an early diagnosis of this devastating condition.

The identification of novel biomarkers for the prediction and/or early diagnosis of sepsis is crucial. Markers such as interleukin-6 (IL-6), C-reactive protein (CRP) and lipopolysaccharide binding protein (LBP) have been proposed for diagnosing or monitoring sepsis.1,2 The latter two biomarkers also increase in patients with inflammation due to trauma or surgery, and therefore their diagnostic relevance in critically ill patients with sepsis is far from perfect.3 Procalcitonin tests also show promise but there is currently insufficient evidence to recommend their routine adoption in the NHS.4 

The Surviving Sepsis Campaign recommends that the first essential step is to identify suspected infection.5 There also needs to be a differential diagnosis between sepsis and non-infectious systemic inflammatory response syndrome (SIRS). The full blood count (FBC) and coagulation screen are among the first laboratory tests available to clinicians and therefore changes in parameters could provide potential biomarkers for infection and sepsis. The Sysmex range of analysers has unique parameters and graphical displays that can be of value to staff looking for signs of sepsis in samples from accident and emergency (A&E) or the intensive care unit (ICU).

White blood cell parameters

Log in or register FREE to read the rest

This story is Premium Content and is only available to registered users. Please log in at the top of the page to view the full text. If you don't already have an account, please register with us completely free of charge.
Register

Upcoming Events

Arab Health 2023

Dubai World Trade Centre
30th January - 2nd February 2023

Access the latest issue of Clinical Services Journal on your mobile device together with an archive of back issues.

Download the FREE Clinical Services Journal app from your device's App store

Upcoming Events

Arab Health 2023

Dubai World Trade Centre
30th January - 2nd February 2023

Access the latest issue of Clinical Services Journal on your mobile device together with an archive of back issues.

Download the FREE Clinical Services Journal app from your device's App store

Step Communications Ltd, Step House, North Farm Road, Tunbridge Wells, Kent TN2 3DR
Tel: 01892 779999 Fax: 01892 616177
www.step-communications.com
© 2022 Step Communications Ltd. Registered in England. Registration Number 3893025